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PhenoCane

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Description

Inflammation is caused by the release of PGE1 Prostaglandin and is sustained by an enzyme called Cyclooxygenase 2 (COX2). If one could inhibit COX2 enzymes, they could control inflammation.

Many years ago drug companies found that aspirin inhibited COX2 but at the same time inhibited COX1 which is a Protective Prostaglandin for the lining of the digestive tract and blood vessels. Without adequate COX1 you can have ulcers and leaking of the blood vessels. So, for temporary use, aspirin is fine but extended use causes serious side effects.

Then came the “miracle” of the COX2 inhibitors – Vioxx, Bextra, Celebrex, etc. These didn’t cause ulcers and weak blood vessels and the expectations were high. But later we found that the great results experienced were offset by the fact that these anti-inflammatory drugs caused heart attacks and strokes because they induced clots in the blood. The risks were so great that the FDA temporarily took them off the market.

Remember that inflammation causes pain – both acute and chronic. If an anti-inflammatory product could be found that would inhibit COX2 without side effects, you could stop the cause of pain.

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Description

Inflammation is caused by the release of PGE1 Prostaglandin and is sustained by an enzyme called Cyclooxygenase 2 (COX2). If one could inhibit COX2 enzymes, they could control inflammation.

Many years ago drug companies found that aspirin inhibited COX2 but at the same time inhibited COX1 which is a Protective Prostaglandin for the lining of the digestive tract and blood vessels. Without adequate COX1 you can have ulcers and leaking of the blood vessels. So, for temporary use, aspirin is fine but extended use causes serious side effects.

Then came the “miracle” of the COX2 inhibitors – Vioxx, Bextra, Celebrex, etc. These didn’t cause ulcers and weak blood vessels and the expectations were high. But later we found that the great results experienced were offset by the fact that these anti-inflammatory drugs caused heart attacks and strokes because they induced clots in the blood. The risks were so great that the FDA temporarily took them off the market.

Remember that inflammation causes pain – both acute and chronic. If an anti-inflammatory product could be found that would inhibit COX2 without side effects, you could stop the cause of pain.

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