Exciting new research indicates that Benfotiamine, (pronounced ben-fo-ta-mean) can block three of the four enzymatic pathways that lead to the formation of Advanced Glycation End Products (AGE’s). AGE’s are a result of glycation, a pathological process that occurs when glucose binds to protein molecules, resulting in the formation of non-functioning structures in the body. People with diabetes often suffer from circulatory difficulties and vision problems etc. These effects are acquired from a build-up of sugar in the tissues. Higher blood glucose levels cause more of these damaging glycation reactions, but even at “normal” glucose levels, our bodies produce glycated end products. Studies have shown that benfotiamine helps maintain healthy cells in the presence of blood glucose by normalizing cellular processes fueled by glucose metabolites. Researchers have reported that Benfotiamine halts much of the sugar accumulation, which is the cause of diabetic vascular complications and supplementing with benfotiamine may lead to a vastly improved quality of life for those with metabolic dysfunction. Four major pathways have been highlighted as causing much of the damage of diabetes, in-essence because they help glucose-derived compounds, called triosephosphates, accumulate in vascular and nerve cells. But the activation of the enzyme transketolase, turns triosephosphates into harmless chemicals. As transketolase is a thiamine-dependent enzyme, it was thought that thiamine, (vitamin B1) could activate them. However, thiamine only activates it about 20 percent, which isn’t enough to stop the glucose-derived compounds accumulating in healthy cells. But recent research has found that benfotiamine increases the levels of transketolase by 300 percent, and also blocks three pathways completely. While its action has not been tested on a fourth pathway that controls nerve cells, it is thought that it may work similarly there. Benfotiamine acts like a biochemical “super-thiamin” because it is fat-soluble, which enables it to access areas of the body that water-soluble thiamine cannot penetrate. That’s why it is so effective in preventing potential damage caused by high glucose levels that flood cells and overwhelm their metabolic machinery. At any rate, blocking three pathways is believed to be enough to prevent many diabetes-related complications. Researchers have reported that Benfotiamine is a huge breakthrough in diabetes researcher and that Benfotiamine may also have important implications for aging. Because metabolic dysfunction leading to diabetes may not be diagnosed as diabetes and many similar complications occur as a result, supplementing with benfotiamine may be a prudent measure for anyone over fifty years of age.
Other Ingredients: modified cellulose (vegetarian capsule), cellulose, silicon dioxide.
Directions: One capsule daily, with or without food.